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KMID : 1059520140580060575
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Journal of the Korean Chemical Society
2014 Volume.58 No. 6 p.575 ~ p.579
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Drug Release from Thermosensitive Liposomes by High-Intensity Focused Ultrasound
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Jeon Ye-Won
Cho Sun-Hang
Han Hee-Dong
Shin Byung-Cheol
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Abstract
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Development of liposomes has been actively studied for effective delivery of drug at tumor site. However, despite their preferential accumulation at tumor site, the therapeutic efficacy of such liposomal drug has been limited because of low drug release. Therefore, we developed a temperature-sensitive liposome (TSL), which can be made to maximize release of drug by external stimulation such as ultrasound. Doxorubicin (DOX) as a model drug was encapsulated into TSL by a pH gradient method. The particle size of the TSL was 142.0 ± 6.24 nm. Surface charge was -10.55 ± 1.12 mV. Release of drug from TSLs was up to 80% within 15 min at over 42 oC measured by fluorescence intensity. Cytotoxicity of released DOX from TSLs with ultrasound was highly increased compared to TSLs without ultrasound. Taken together, we demonstrate that temperature sensitive drug release from TSLs with ultrasound, which may be useful for cancer therapy to increase drug concentration at tumor site by external stimulation.
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KEYWORD
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Liposome, Drug release, Doxorubicin, Ultrasound
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